Schedule

Conference Program

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  • Sunday24/9/2017
  • Monday25/9/2017
  • Tuesday26/9/2017
  • Wednesday27/9/2017
  • Thursday28/9/2017
15:00

Registration

17:00

Welcome and Introductory Remarks

Welcome to DNA repair conference


Gianluca Tell
Welcome and Introductory Remarks
17:00
Alberto Felice De Toni
Institutional Welcomes
17:15
17:50

Opening Plenary/Keynote Lecture


Eugenia Dogliotti
Opening Keynote Introduction
17:45
Tomas Lindahl
Enzymatic surveillance of DNA instability
18:00
19:30

Buffet

(sponsored by the Organizers) for the Invited speakers and paying Registrants


Spouse program

Optional and fee-paying with limited availability

11:30 – 12:30

Guided visits to historical Udine

8:30

Session 1 - Replication Stress

10:40

Coffee break


11:10

Session 2 - DNA editing: Mechanisms underlying mutational signatures in human cancers


Robert W. Sobol
Session Chair
11:00
Ludmil Alexandrov
Signatures of mutational processes in human cancer
11:10
David M. Wilson III
Repair mechanisms for endogenous DNA damage
11:40
Samuel H. Wilson
Modulating the DNA polymerase reaction equilibrium through chemical biology
12:10
12:40

Speakers chosen from submitted abstracts


Nima Mosammaparast
The ASCC complex mediates a ubiquitin-dependent signaling axis specific for ALKBH-mediated demethylation repair
12:40
Alex Pines
TRIC chaperonin control transcription after UV damage by regulating Cockayne Syndrome protein A
12:50
13:00

Lunch - provided


14:30

Session 3 - Regulatory mechanisms of RNA functions in genome stability


Gianluca Tell
Session Chair
14:30
Martin A.M. Reijns
Genome-embedded ribonucleotides: the good, the bad and the ugly
14:40
Francesca Storici
DNA repair by template RNA
15:10
Fabrizio d’Adda di Fagagna
The role of non non-coding RNA in the DNA damage response
15:40
Hilde Nilsen
Implication of SMUG1 RNA processing activity for telomere maintenance
16:10
16:30

Coffee break


17:00

Poster session


19:00

Dinner - on your own


Spouse program

Optional and fee-paying with limited availability

11:30

Guided visits to historical Udine

17:45

Guided visits to historical Udine

8:30

Session 4 - Non-canonical action and novel regulators of DNA repair

10:30

Coffee break


11:00

Session 5 - DNA damage, epigenetics and DNA repair


David M. Wilson III
Session Chair
11:00
Roderick J. O’Sullivan
Interrogating the mechanism of Alternative Lengthening of Telomeres
11:10
Gaëlle Legube
Chromosome and chromatin dynamics during DNA double strand break repair
11:40
Primo Schär
DNA repair mediated DNA demethylation generates site-directed chromatin plasticity
12:10
Boris Pfander
Chromatin constitutes a bottleneck in the response to double strand breaks
12:40
13:00

Lunch - provided at the Cafeteria of ‘Renati Campus’


14:30

Session 6 - Stability of the genome in aging and non-neoplastic disease


Eugenia Dogliotti
Session Chair
14:30
Björn Schumacher
Non-cell-autonomous regulation of the DNA damage response
14:40
Tohru Minamino
A critical role of cellular senescence in metabolic and cardiovascular disease
15:10
Vilhelm Bohr
DNA damage, neurodegeneration and mitochondrial dysfunction
15:40
Pier Giorgio Mastroberardino
DNA damage and repair in chronic neurodegeneration
16:10
16:30

Coffee break


17:00

Poster session


19:00

Dinner - on your own


Spouse program

Optional and fee-paying with limited availability

8:00 – 19:00

Visit to the Roman city of Aquileia and to the “Miramare Castle”

11:30

Guided visits to historical Udine

17:45

Guided visits to historical Udine

8:30

Session 7 - Advanced technologies for analysis of DNA repair and the DNA damage response

10:10

Speakers chosen from submitted abstracts


Altaf Wani
Regulation of post-repair restoration of epigenetic chromatin mark
10:10
Olga Lavrik
Protein-protein interactions operating in base excision DNA repair
10:20
10:30

Coffee break


11:00

Session 8 - Poly(ADP-ribosyl)ation in the DNA damage response: Pre-clinical and translational aspects


Alexander Bürkle
Session Chair
11:00
Françoise Dantzer
Poly(ADP-ribose) polymerase 3 (PARP3) in genome integrity and beyond
11:10
Haico Van Attikum
Regulation and dynamics of DNA repair in a chromatin context
11:40
Conchita Vens
Towards radiotherapy and PARP inhibitor combination: mechanism and clinical aspects
12:10
12:40

Speakers chosen from submitted abstracts


Muralidhar Hegde
New Mechanism of Genome damage and Repair defects in motor neuron disease: Role of TDP-43
12:40
Sathya Balachander
Ribose-seq upgraded: a robust technique to map ribonucleotides incorporated in any genomic DNA
12:50
13:00

Lunch - provided at the Cafeteria of ‘Renati Campus’


14:00

Planned trip to the UNESCO World Heritage Sites: Aquileia and Cividale


18:30

Dinner partially sponsored by the Organizers

Location: Villa DeClaricini (http://www.declaricini.it/)


8:30

Session 9 - Defects in the DNA damage response as targets for personalized therapeutic approaches

10:30

Coffee break


11:00

Session 10 – Cell type and DNA damage specificity in DNA repair


Eugenia Dogliotti
Session Chair
11:00
Leona D. Samson
Cell Specific Responses to Alkylation and Inflammation
11:20
Bruce Demple
Crosslinks produced during attempted DNA repair
11:40
Bernd Kaina
DNA repair and death regulation in human myeloid immune cells
12:10
12:40

Speakers chosen from submitted abstracts


13:00

Lunch - provided at the Cafeteria of ‘Renati Campus’


14:30

Closing Plenary


Robert W. Sobol
Closing Keynote Introduction
14:30
Philip C. Hanawalt
From Repair Replication to R-loops in half-a-century
14:40
15:40

Public announcement of the names of the Travel Fellowships awardees for best Poster Presentation


16:00

Thank you


Gianluca Tell
Closing remarks
16:00

Spouse program

Optional and fee-paying with limited availability

11:30

Guided visits to historical Udine

17:45

Guided visits to historical Udine