The conference

The 6th US-EU Conference on Repair of Endogenous DNA Damage will be held September 24-28, 2017 in Udine, Italy.

Robert W. Sobol (USA), Eugenia Dogliotti (Italy), Alexander Bürkle (Germany) and Gianluca Tell (Italy) are the Conference Organizers.

The Local Conference Organizers are the followings: Gianluca Tell (University of Udine), Claudio Brancolini (University of Udine), Gianni Del Sal (University of Trieste), Stefan Schoeftner (University of Trieste) and Paolo Ermano (University of Udine).

Dr. Sobol, chief of the Molecular and Metabolic Oncology Program at the Mitchell Cancer Institute (USA), will manage all the organizational aspects regarding US participants, and, with Prof. Tell from University of Udine, Dr. Dogliotti from the Istituto Superiore di Sanità (National Health Institute) and Prof. Bürkle from Costanza University will co-organize the conference.

Already several important international institutions have joined the committee to support the organization of this prestigious conference

  • University of Udine (Italy)
  • University of Trieste (Italy)
  • School of Advanced Studies, Trieste (SISSA)
  • Istituto Superiore di Sanità (Roma)
  • University of South Alabama (USA)
  • University of Konstanz (DE)
  • AREA Science Park, Trieste
  • Friuli Innovazione (Udine)
  • Consorzio per la Biomedicina Molecolare, CBM, Trieste
  • National Institutes of Health, NIH (USA)

The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging is indeed the major theme of this conference.

Recently, there has been an explosion-like increase of information on cancer genomes; the development of novel technologies for genome editing; visualizing DNA repair complexes; the role for RNA in genome stability; novel mechanisms of DNA repair and epigenetics; and the role of aging and environmental exposures in genome stability. A major goal of this meeting is to foster collaborative research on the cellular processes that affect genomic instability in cancer. The role of endogenous DNA damage, in particular oxidative DNA damage, as a driver of normal and accelerated aging and the study of premature aging syndromes remain important areas of interest.

Insights from rare inherited human diseases with defects in the DNA damage response continue to illuminate links between endogenous DNA damage and cancer, aging and neurologic disease.

To promote the translation of knowledge about the sources and repair of endogenous DNA lesions into interventions that improve global human health, this meeting will stimulate collaborative translational research focused on the identification of new therapeutic targets and the development of treatment strategies that either regulate DNA repair pathways in order to enhance cancer treatment, delay neurodegeneration, or reduce the pathological changes associated with aging.

A key objective of the 2017 meeting is to provide an environment for both early career and senior investigators of diverse backgrounds to communicate their latest results on relevant scientific topics and establish interactions that will not only strengthen the numerous basic science and translational research efforts in this arena, but also enhance the development of the next generation of researchers.

Thanks to the presence of about 40 invited speakers, the conference will welcome around 200 participants from all over the world: scholars, researchers, doctors, graduate students, technologists. Therefore, this meeting will create an environment where young scholars and scientific experts from different fields share the latest results on these important research topics, and establish relationships that will not only strengthen research efforts on this scientific field, but can positively influence the growth of a new generation of scientists.

The meeting will be held at the University of Udine, a city at the centre of Europe that has been chosen because it can offer a unique atmosphere to develop collaborations. Indeed, the city will allow optimal interaction between participants, ensuring different moments of inspiring collaborations between American and European scientists. In addition, in the city there will be organized several promotional events of this congress in order to diffuse knowledge and awareness on the topics discussed.

In this, the 6th conference in this series, we are honoured by the presence of a special guest, the winner of the 2015 Nobel Prize in Chemistry, Dr. Tomas Lindahl who has contributed substantially to the discovery of the mechanisms of repair of damage caused by reactive oxygen species and DNA that are involved in many human diseases including aging.