6^th EU-US Conference on
Repair of endogenous DNA
damage

6^th EU-US Conference on
Repair of endogenous DNA
damage

September 24^th-28^th 2017
University of Udine, Italy

See the schedule

About the 6^th EU-US Conference on Repair of endogenous DNA damage

The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging is indeed the major theme of this conference.

Conference Program

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Sunday24/9/2017
Monday25/9/2017
Tuesday26/9/2017
Wednesday27/9/2017
Thursday28/9/2017

15:00

Registration

17:00

Welcome and Introductory Remarks

Welcome to DNA repair conference

Gianluca Tell

Welcome and Introductory Remarks

17:00

Alberto Felice De Toni

Institutional Welcomes

17:15

17:50

Opening Plenary/Keynote Lecture

Eugenia Dogliotti

Opening Keynote Introduction

17:45

Tomas Lindahl

Enzymatic surveillance of DNA instability

18:00

19:30

Buffet

(sponsored by the Organizers) for the Invited speakers and paying Registrants

Spouse program

Optional and fee-paying with limited availability

11:30 – 12:30

Guided visits to historical Udine

8:30

Session 1 - Replication Stress

Alexander Bürkle

Session Chair

8:30

Hocine Mankouri

Analysis of replication-associated mutagenesis at a single stalled replication fork

8:40

Dana Branzei

Molecular studies of DDX11/Chl1 helicase implicated in the Warsaw breakage syndrome

9:10

Matthias Dobbelstein

p53 and checkpoint signaling as determinants of DNA replication stress

9:40

Alessandro Vindigni

New Mechanisms of Replication Stress Response to Cancer Chemotherapeutics

10:10

10:40

Coffee break

11:10

Session 2 - DNA editing: Mechanisms underlying mutational signatures in human cancers

Robert W. Sobol

Session Chair

11:00

Ludmil Alexandrov

Signatures of mutational processes in human cancer

11:10

David M. Wilson III

Repair mechanisms for endogenous DNA damage

11:40

Samuel H. Wilson

Modulating the DNA polymerase reaction equilibrium through chemical biology

12:10

12:40

Speakers chosen from submitted abstracts

Nima Mosammaparast

The ASCC complex mediates a ubiquitin-dependent signaling axis specific for ALKBH-mediated demethylation repair

12:40

Alex Pines

TRIC chaperonin control transcription after UV damage by regulating Cockayne Syndrome protein A

12:50

13:00

Lunch - provided

14:30

Session 3 - Regulatory mechanisms of RNA functions in genome stability

Gianluca Tell

Session Chair

14:30

Martin A.M. Reijns

Genome-embedded ribonucleotides: the good, the bad and the ugly

14:40

Francesca Storici

DNA repair by template RNA

15:10

Fabrizio d’Adda di Fagagna

The role of non non-coding RNA in the DNA damage response

15:40

Hilde Nilsen

Implication of SMUG1 RNA processing activity for telomere maintenance

16:10

16:30

Coffee break

17:00

Poster session

19:00

Dinner - on your own

Spouse program

Optional and fee-paying with limited availability

11:30

Guided visits to historical Udine

17:45

Guided visits to historical Udine

8:30

Session 4 - Non-canonical action and novel regulators of DNA repair

Eugenia Dogliotti

Session Chair

8:30

Patrick Sung

Novel role of the BRCA1-BARD1 complex in RAD51-mediated homologous recombination

8:40

John Tainer

Flap endonuclease 1 employs DNA sculpting and phosphate steering to ensure specific 5´-flap incision to prevent genome instability

9:10

Alan Tomkinson

Targeting mitochondrial DNA repair in cancer cells

9:40

Jean-Marc Egly

Cockayne syndrome A and B proteins regulate transcription arrest through a ubiquitin/proteasome degradation process

10:10

10:30

Coffee break

11:00

Session 5 - DNA damage, epigenetics and DNA repair

David M. Wilson III

Session Chair

11:00

Roderick J. O’Sullivan

Interrogating the mechanism of Alternative Lengthening of Telomeres

11:10

Gaëlle Legube

Chromosome and chromatin dynamics during DNA double strand break repair

11:40

Primo Schär

DNA repair mediated DNA demethylation generates site-directed chromatin plasticity

12:10

Boris Pfander

Chromatin constitutes a bottleneck in the response to double strand breaks

12:40

13:00

Lunch - provided at the Cafeteria of ‘Renati Campus’

14:30

Session 6 - Stability of the genome in aging and non-neoplastic disease

Eugenia Dogliotti

Session Chair

14:30

Björn Schumacher

Non-cell-autonomous regulation of the DNA damage response

14:40

Tohru Minamino

A critical role of cellular senescence in metabolic and cardiovascular disease

15:10

Vilhelm Bohr

DNA damage, neurodegeneration and mitochondrial dysfunction

15:40

Pier Giorgio Mastroberardino

DNA damage and repair in chronic neurodegeneration

16:10

16:30

Coffee break

17:00

Poster session

19:00

Dinner - on your own

Spouse program

Optional and fee-paying with limited availability

8:00 – 19:00

Visit to the Roman city of Aquileia and to the “Miramare Castle”

11:30

Guided visits to historical Udine

17:45

Guided visits to historical Udine

8:30

Session 7 - Advanced technologies for analysis of DNA repair and the DNA damage response

Alan Tomkinson

Session Chair

8:30

Elisa Ferrando-May

Optical control and real-time imaging of DNA damage and repair

8:40

Michele Morgante

NGS-based technologies for studying genome stability and structural diversity

9:10

Bret D. Freudenthal

APE1 cleavage mechanisms during DNA repair

9:40

10:10

Speakers chosen from submitted abstracts

Altaf Wani

Regulation of post-repair restoration of epigenetic chromatin mark

10:10

Olga Lavrik

Protein-protein interactions operating in base excision DNA repair

10:20

10:30

Coffee break

11:00

Session 8 - Poly(ADP-ribosyl)ation in the DNA damage response: Pre-clinical and translational aspects

Alexander Bürkle

Session Chair

11:00

Françoise Dantzer

Poly(ADP-ribose) polymerase 3 (PARP3) in genome integrity and beyond

11:10

Haico Van Attikum

Regulation and dynamics of DNA repair in a chromatin context

11:40

Conchita Vens

Towards radiotherapy and PARP inhibitor combination: mechanism and clinical aspects

12:10

12:40

Speakers chosen from submitted abstracts

Muralidhar Hegde

New Mechanism of Genome damage and Repair defects in motor neuron disease: Role of TDP-43

12:40

Sathya Balachander

Ribose-seq upgraded: a robust technique to map ribonucleotides incorporated in any genomic DNA

12:50

13:00

Lunch - provided at the Cafeteria of ‘Renati Campus’

14:00

Planned trip to the UNESCO World Heritage Sites: Aquileia and Cividale

18:30

Dinner partially sponsored by the Organizers

Location: Villa DeClaricini (http://www.declaricini.it/)

8:30

Session 9 - Defects in the DNA damage response as targets for personalized therapeutic approaches

Robert W. Sobol

Session Chair

8:30

Trey Ideker

Mapping the DNA damage response hierarchy by analysis of systematic genetic networks

8:40

Chris Bakkenist

ATR kinase inhibitors attenuate radiation-induced T cell exhaustion and potentiate T cell activity in the tumor microenvironment

9:10

Randi Gussgard Syljuåsen

Mechanisms and consequences of basal ATR/Chk1 activity in human cells

9:40

Nina Gustafsson

Protecting the genome through metabolic enzymes

11:10

10:30

Coffee break

11:00

Session 10 – Cell type and DNA damage specificity in DNA repair

Eugenia Dogliotti

Session Chair

11:00

Leona D. Samson

Cell Specific Responses to Alkylation and Inflammation

11:20

Bruce Demple

Crosslinks produced during attempted DNA repair

11:40

Bernd Kaina

DNA repair and death regulation in human myeloid immune cells

12:10

12:40

Speakers chosen from submitted abstracts

13:00

Lunch - provided at the Cafeteria of ‘Renati Campus’

14:30

Closing Plenary

Robert W. Sobol

Closing Keynote Introduction

14:30

Philip C. Hanawalt

From Repair Replication to R-loops in half-a-century

14:40

15:40

Public announcement of the names of the Travel Fellowships awardees for best Poster Presentation

16:00

Thank you

Gianluca Tell

Closing remarks

16:00

Spouse program

Optional and fee-paying with limited availability

11:30

Guided visits to historical Udine

17:45

Guided visits to historical Udine

The speakers

Tomas Lindahl image

Tomas Lindahl

Nobel Prize in Chemistry

Swedish-born, in 2015 Lindahl was awarded the Nobel Prize in Chemistry jointly with Paul L. Modrich and Aziz Sancar for mechanistic studies of DNA repair.

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Philip C. Hanawalt

American biologist

Hanawalt has received many honors and awards for his contributions to DNA studies, in particular on lesion sensing and decision points in the DNA repair response.

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Gianluca Tell

Organizer

Gianluca Tell is Associate Professor of Molecular Biology at the University of Udine and in 2013 he identified one of the processes that allow cancer cells to "resist" to the drugs.

See all the organizers

Many others

Speakers

More than 34 speakers are waiting for you.

Wilsons is one of the leading researchers in the field of Base Excision Repair (BER) and has isolated several BER

See all the speakers

Features

DNA stability and replication
DNA Editing: Mechanisms underlying mutational signatures in human cancers
DNA damage response: Pre-clinical and translational aspects
Defects in the DNA damage response as targets for personalized therapeutic approaches
Stability of the genome in aging and non-neoplastic disease
Advanced technologies for analysis of DNA repair
Regulatory mechanisms of RNA functions in genome stability
DNA damage and epigenetics
DNA repair and environmental pollutants

Our plans and pricings

For a full list of prices please take a look at our table of pricing plans.

650^€

Regular registrants

This includes:

all the scientific sessions
welcome reception, lunch, beverages

Free

Uniud, Units and Sissa students*

This includes:

all the scientific sessions

300^€

Students outside Friuli Venezia Giulia*

This includes:

all the scientific sessions
welcome reception, lunch, beverages

*Students means all students including PostDoc with less than 2 years after the PhD Title.
They should provide a declaration by a Mentor or academic institution they currently work.