6^th EU-US Conference on
Repair of endogenous DNA
damage

6^th EU-US Conference on
Repair of endogenous DNA
damage

September 24^th-28^th 2017
University of Udine, Italy

See the schedule See the speakers

Time until the event

24^th September

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About the 6^th EU-US Conference on Repair of endogenous DNA damage

The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging is indeed the major theme of this conference.

Specially organized events

Introductory lesson

An introductory lesson will be held in the main square of the city the week before the meeting to prepare the community.

Leisure activities

Activities addressed to children of the elementary/middle school will be organized in cooperation with the Toy Library (ludoteca).

Meetings in schools

At the beginning of the school year, some teachers of biology will speak to the students to give glance of the conference topics.

Games in the square

Meetings with games will be organized using the experience of organization such as the Immaginario Scientifico or Kaleidoscienza.

Conference Program

DOWNLOAD .PDF schedule

Sunday24/9/2017
Monday25/9/2017
Tuesday26/9/2017
Wednesday27/9/2017
Thursday28/9/2017

17:00

Welcome Remarks

Welcome to DNA repair conference

Gianluca Tell

Welcome Remarks

17:30

17:50

Opening Plenary/Keynote Lecture

Eugenia Dogliotti

Opening Keynote Introduction

17:50

Tomas Lindahl

Base excision repair

18:00

19:00

Buffet

8:30

Session 1 - Replication Stress

Alexander Bürkle

Session Leader

8:30

Hocine Mankouri

Analysis of Mutagenic events occurring at a Stalled Replication Fork

8:40

Dana Branzei

Roles of Smc5/6 in Endogenous DNA damage tolerance and replication through natural pausing sites

9:10

Matthias Dobbelstein

p53 and checkpoint signaling as determinants of DNA replication stress

9:40

Alessandro Vindigni

New Mechanisms of Replication Stress Response to Cancer Chemotherapeutics

10:10

10:40

Coffee break

11:10

Session 2 - DNA editing: Mechanisms underlying mutational signatures in human cancers

Robert W. Sobol

Session Leader

11:00

Ludmil Alexandrov

Signatures of mutational processes in human cancer

11:10

David M. Wilson III

Repair of endogenous DNA damage in disease and aging

11:40

Samuel H. Wilson

Insight on how DNA polymerases select the incoming nucleotide

12:10

13:00

Lunch - provided

14:30

Session 3 - Regulatory mechanisms of RNA functions in genome stability

Gianluca Tell

Session Leader

14:30

Martin A.M. Reijns

Genome-embedded ribonucleotides: the good, the bad and the ugly

14:40

Francesca Storici

DNA repair by template RNA

15:10

Fabrizio d’Adda di Fagagna

The role of non non-coding RNA in the DNA damage response

15:40

Hilde Nilsen

Implication of SMUG1 RNA processing activity for telomere maintenance

16:10

16:30

Coffee break

17:00

Poster session

19:00

Dinner - on your own

8:30

Session 4 - Non-canonical action and novel regulators of DNA repair

Eugenia Dogliotti

Session Leader

8:00

Patrick Sung

Synaptic Complex Assembly in Homology-directed DNA Break Repair

8:10

Joe Jiricny

The multifaceted Mismatch Repair

8:40

Alan Tomkinson

Targeting mitochondrial DNA repair in cancer cells

9:10

Jean-Marc Egly

Egly: CSA/CSB, transcription coupled repair factors and/or components of the ubiquitin/proteasome degradation

9:40

9:00

Spouse Program

Trip to Rivolto Air Force Base, headquarters of Frecce Tricolori (national aerobatic demonstration team)

10:30

Coffee break

11:00

Session 5 - DNA damage, epigenetics and DNA repair

David M. Wilson III

Session Leader

11:00

Roderick J. O’Sullivan

Interrogating the mechanism of Alternative Lengthening of Telomeres

11:10

Gaëlle Legube

Chromosome and chromatin dynamics following DNA Double Strand Breaks

11:40

Primo Schär

DNA Repair Mediated DNA Demethylation and Epigenetic Plasticity

12:10

Boris Pfander

Control of DSB repair by chromatin and cell cycle

12:40

13:00

Lunch - provided

14:30

Session 6 - Stability of the genome in aging and non-neoplastic disease

Eugenia Dogliotti

Session Leader

14:30

Björn Schumacher

Non-cell-autonomous regulation of the DNA damage response

14:40

Tohru Minamino

The role of cellular senescence in lifestyle-related disease

15:10

Vilhelm Bohr

Signaling from nuclear DNA damage to mitochondria in neurodegeneration and aging

15:40

Pier Giorgio Mastroberardino

DNA damage and repair in chronic neurodegeneration

16:10

16:30

Coffee break

17:00

Poster session

19:00

Dinner - on your own

8:30

Session 7 - Advanced technologies for analysis of DNA repair and the DNA damage response

Alan Tomkinson

Session Leader

8:30

Elisa Ferrando-May

Optical control and real-time imaging of DNA damage and repair

8:40

Michele Morgante

NGS-based technologies for studying genome stability and structural diversity

9:10

Bret D. Freudenthal

Molecular Snapshots of DNA Damage Processing

9:40

10:30

Coffee break

11:00

Session 8 - Poly(ADP-ribosyl)ation in the DNA damage response: Pre-clinical and translational aspects

Alexander Bürkle

Session Leader

11:00

Françoise Dantzer

PARP3 in genome integrity and beyond

11:10

Haico Van Attikum

Regulation and dynamics of DNA repair in a chromatin context

11:40

Conchita Vens

Towards radiotherapy and PARP inhibitor combination: mechanism and clinical aspects

12:10

13:00

Lunch - provided

14:00

Planned trip to the UNESCO World Heritage Sites: Aquileia and Cividale

19:00

Dinner sponsored by the Organizers Villa DeClaricini

8:30

Session 9 - Defects in the DNA damage response as targets for personalized therapeutic approaches

Robert W. Sobol

Session Leader

8:30

Trey Ideker

Towards a systematic map of DNA damage response using combinatorial CRISPR-Cas9 and hierarchical modeling

8:40

Chris Bakkenist

ATR kinase inhibitors for the treatment of cancer

9:10

Randi Gussgard Syljuåsen

ATR activation via the transcription machinery

9:40

Nina Gustafsson

Protecting the genome through metabolic enzymes

11:10

10:30

Coffee break

11:00

Session 10 - DNA repair and response to complex environmental genotoxins

Eugenia Dogliotti

Session Leader

11:00

Leona D. Samson

Cell Specific Responses to Alkylation and Inflammation

11:20

Bruce Demple

DNA-Protein Crosslinks Produced During Attempted DNA Repair

11:40

Bernd Kaina

DNA repair and death regulation in human myeloid immune cells

12:10

13:00

Lunch - provided

14:30

Closing Plenary

Robert W. Sobol

Closing Keynote Introduction

14:30

Philip C. Hanawalt

Excision Repair

14:40

16:00

Thank you

Gianluca Tell

Closing remarks

16:00

The speakers

Tomas Lindahl image

Tomas Lindahl

Nobel Prize in Chemistry

Swedish-born, in 2015 Lindahl was awarded the Nobel Prize in Chemistry jointly with Paul L. Modrich and Aziz Sancar for mechanistic studies of DNA repair.

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Philip C. Hanawalt

American biologist

Hanawalt has received many honors and awards for his contributions to DNA studies, in particular on lesion sensing and decision points in the DNA repair response.

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Gianluca Tell

Organizer

Gianluca Tell is Associate Professor of Molecular Biology at the University of Udine and in 2013 he identified one of the processes that allow cancer cells to "resist" to the drugs.

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Many others

Speakers

More than 34 speakers are waiting for you.

Wilsons is one of the leading researchers in the field of Base Excision Repair (BER) and has isolated several BER

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Features

DNA stability and replication
DNA Editing: Mechanisms underlying mutational signatures in human cancers
DNA damage response: Pre-clinical and translational aspects
Defects in the DNA damage response as targets for personalized therapeutic approaches
Stability of the genome in aging and non-neoplastic disease
Advanced technologies for analysis of DNA repair
Regulatory mechanisms of RNA functions in genome stability
DNA damage and epigenetics
DNA repair and environmental pollutants

Our plans and pricings

For a full list of prices please take a look at our table of pricing plans.

650^€

Regular registrants

This includes:

all the scientific sessions
welcome reception, lunch, beverages

order now

Free

Uniud, Units and Sissa students*

This includes:

all the scientific sessions

SOLD OUT

300^€

Students outside Friuli Venezia Giulia*

This includes:

all the scientific sessions
welcome reception, lunch, beverages

order now

*Students means all students including PostDoc with less than 2 years after the PhD Title.
They should provide a declaration by a Mentor or academic institution they currently work.