Time until the event

24th September

About the 6th EU-US Conference on Repair of endogenous DNA damage

The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging is indeed the major theme of this conference.


University of Udine logo

Specially organized events

Introductory lesson

An introductory lesson will be held in the main square of the city the week before the meeting to prepare the community.

Leisure activities

Activities addressed to children of the elementary/middle school will be organized in cooperation with the Toy Library (ludoteca).

Meetings in schools

At the beginning of the school year, some teachers of biology will speak to the students to give glance of the conference topics.

Games in the square

Meetings with games will be organized using the experience of organization such as the Immaginario Scientifico or Kaleidoscienza.

Conference Program

  • Sunday24/9/2017
  • Monday25/9/2017
  • Tuesday26/9/2017
  • Wednesday27/9/2017
  • Thursday28/9/2017
17:00

Welcome Remarks

17:50

Opening Plenary/Keynote Lecture


Eugenia Dogliotti
Opening Keynote Introduction
Tomas Lindahl
Base excision repair
19:00

Buffet


8:30

Session 1 - Replication Stress

10:40

Coffee break


11:10

Session 2 - DNA editing: Mechanisms underlying mutational signatures in human cancers


Robert W. Sobol
Session Leader
Ludmil Alexandrov
Signatures of mutational processes in human cancer
David M. Wilson III
Repair of endogenous DNA damage in disease and aging
Samuel H. Wilson
Insight on how DNA polymerases select the incoming nucleotide
13:00

Lunch - provided


14:30

Session 3 - Regulatory mechanisms of RNA functions in genome stability


Gianluca Tell
Session Leader
Martin A.M. Reijns
Genome-embedded ribonucleotides: the good, the bad and the ugly
Francesca Storici
DNA repair by template RNA
Fabrizio d’Adda di Fagagna
The role of non non-coding RNA in the DNA damage response
Hilde Nilsen
Implication of SMUG1 RNA processing activity for telomere maintenance
16:30

Coffee break


17:00

Poster session


19:00

Dinner - on your own


8:30

Session 4 - Non-canonical action and novel regulators of DNA repair

9:00

Spouse Program

Trip to Rivolto Air Force Base, headquarters of Frecce Tricolori (national aerobatic demonstration team)


10:30

Coffee break


11:00

Session 5 - DNA damage, epigenetics and DNA repair


David M. Wilson III
Session Leader
Roderick J. O’Sullivan
Interrogating the mechanism of Alternative Lengthening of Telomeres
Gaëlle Legube
Chromosome and chromatin dynamics following DNA Double Strand Breaks
Primo Schär
DNA Repair Mediated DNA Demethylation and Epigenetic Plasticity
Boris Pfander
Control of DSB repair by chromatin and cell cycle
13:00

Lunch - provided


14:30

Session 6 - Stability of the genome in aging and non-neoplastic disease


Eugenia Dogliotti
Session Leader
Björn Schumacher
Non-cell-autonomous regulation of the DNA damage response
Tohru Minamino
The role of cellular senescence in lifestyle-related disease
Vilhelm Bohr
Signaling from nuclear DNA damage to mitochondria in neurodegeneration and aging
Pier Giorgio Mastroberardino
DNA damage and repair in chronic neurodegeneration
16:30

Coffee break


17:00

Poster session


19:00

Dinner - on your own


8:30

Session 7 - Advanced technologies for analysis of DNA repair and the DNA damage response

10:30

Coffee break


11:00

Session 8 - Poly(ADP-ribosyl)ation in the DNA damage response: Pre-clinical and translational aspects


Alexander Bürkle
Session Leader
Françoise Dantzer
PARP3 in genome integrity and beyond
Haico Van Attikum
Regulation and dynamics of DNA repair in a chromatin context
Conchita Vens
Towards radiotherapy and PARP inhibitor combination: mechanism and clinical aspects
13:00

Lunch - provided


14:00

Planned trip to the UNESCO World Heritage Sites: Aquileia and Cividale


19:00

Dinner sponsored by the Organizers Villa DeClaricini


8:30

Session 9 - Defects in the DNA damage response as targets for personalized therapeutic approaches

10:30

Coffee break


11:00

Session 10 - DNA repair and response to complex environmental genotoxins


Eugenia Dogliotti
Session Leader
Leona D. Samson
Cell Specific Responses to Alkylation and Inflammation
Bruce Demple
DNA-Protein Crosslinks Produced During Attempted DNA Repair
Bernd Kaina
DNA repair and death regulation in human myeloid immune cells
13:00

Lunch - provided


14:30

Closing Plenary


Robert W. Sobol
Closing Keynote Introduction
Philip C. Hanawalt
Excision Repair
16:00

Thank you


Gianluca Tell
Closing remarks

The speakers

Tomas Lindahl image
Tomas Lindahl
Nobel Prize in Chemistry

Swedish-born, in 2015 Lindahl was awarded the Nobel Prize in Chemistry jointly with Paul L. Modrich and Aziz Sancar for mechanistic studies of DNA repair.

Philip C. Hanawalt
American biologist

Hanawalt has received many honors and awards for his contributions to DNA studies, in particular on lesion sensing and decision points in the DNA repair response.

Gianluca Tell
Organizer

Gianluca Tell is Associate Professor of Molecular Biology at the University of Udine and in 2013 he identified one of the processes that allow cancer cells to "resist" to the drugs.

Many others
Speakers

More than 34 speakers are waiting for you.

Wilsons is one of the leading researchers in the field of Base Excision Repair (BER) and has isolated several BER

Features

  • DNA stability and replication
  • DNA Editing: Mechanisms underlying mutational signatures in human cancers
  • DNA damage response: Pre-clinical and translational aspects
  • Defects in the DNA damage response as targets for personalized therapeutic approaches
  • Stability of the genome in aging and non-neoplastic disease
  • Advanced technologies for analysis of DNA repair
  • Regulatory mechanisms of RNA functions in genome stability
  • DNA damage and epigenetics
  • DNA repair and environmental pollutants
  • University of Udine logo
  • University of Trieste logo
  • Sissa Logo
  • Istituto Superiore di Sanità logo
  • University of South Alabama logo
  • University of Konstanz logo
  • AREA Science Park logo
  • Friulinnovazione logo
  • Friuliformazione logo
  • Centro Studi Fegato logo
  • Consorzio per la Biomedicina Molecolare logo
  • National Institutes of Health logo
  • Udine logo
  • Confindustria Udine logo
  • Regione autonoma Friuli Venezia Giulia logo

Our plans and pricings

For a full list of prices please take a look at our table of pricing plans.

650

Regular registrants

This includes:

  • all the scientific sessions
  • welcome reception, lunch, beverages
order now

Free

Uniud, Units and Sissa students*

This includes:

  • all the scientific sessions
SOLD OUT

300

Students outside Friuli Venezia Giulia*

This includes:

  • all the scientific sessions
  • welcome reception, lunch, beverages
order now

*Students means all students including PostDoc with less than 2 years after the PhD Title.
They should provide a declaration by a Mentor or academic institution they currently work.